منابع مشابه
Chromothripsis
to determine whether C is part of the mechanism by which A contributes to B. Biologists use convergency and consistency amongst these experiments to judge the strength of any causal assertion. Therefore, in research maps convergency and consistency amongst results increases the score assigned to each edge, while contradictory results have the opposite effect. By selecting any one edge in a part...
متن کاملTelomere dysfunction and chromothripsis.
Chromothripsis is a recently discovered form of genomic instability, characterized by tens to hundreds of clustered DNA rearrangements resulting from a single dramatic event. Telomere dysfunction has been suggested to play a role in the initiation of this phenomenon, which occurs in a large number of tumor entities. Here, we show that telomere attrition can indeed lead to catastrophic genomic e...
متن کاملChromothripsis in Lipoblastoma
Lipoblastoma is a benign tumor that often has rearrangements of the 8q11-13 region targeting the PLAG1 gene, which is involved in the process of tumourigenesis. We described a signature of chromotripsis in a thigh lipoblastoma, as first report of chromotripsis in a benign tumor. was performed to make a definitive diagnosis. Histopathological examination revealed a lipoblastoma, with a character...
متن کاملThe elusive evidence for chromothripsis
The chromothripsis hypothesis suggests an extraordinary one-step catastrophic genomic event allowing a chromosome to 'shatter into many pieces' and reassemble into a functioning chromosome. Recent efforts have aimed to detect chromothripsis by looking for a genomic signature, characterized by a large number of breakpoints (50-250), but a limited number of oscillating copy number states (2-3) co...
متن کاملIn Brief: Chromothripsis and cancer.
Chromothripsis is a one-step catastrophic event which plays an important role during cancer development. During chromothripsis, tens to hundreds of genomic rearrangements can occur within localized regions of the genome, and lead to the simultaneous creation of multiple cancer-driving aberrations. Given that chromothripsis has a cancer-wide incidence of 2-3%, its recent discovery has significan...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2015
ISSN: 1538-4101,1551-4005
DOI: 10.1080/15384101.2015.1068483